Users are welcome to use the "guest" account (password "anonymous") but they should be aware that all analyses on this account are removed each night. Further, all results are visible to other users.
As you may have noticed, with Professor Neil Kelleher's move to Northwestern University, the URL has changed. Update your bookmarks to http://prosightptm2.northwestern.edu
ProSightPC 2.0 is complete and is shipping. Contact your local Thermo Fisher sales representative for more information.
Digested proteome warehouses will soon be available. A PTM Warehouse™ is unique in that it retains all of the PTM, alternative splice and SNP information found in our intact protein warehouses on the peptide level giving users the ability to search peptide tandem MS data for valuable PTMs.
Please continue to give us feedback to update and improve ProSightPTM.
A article describing the new features in ProSight PTM 2.0 can be found on-line:
ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry
Leonid Zamdborg; Richard D. LeDuc; Kevin J. Glowacz; Yong-Bin Kim; Vinayak Viswanathan; Ian T. Spaulding; Bryan P. Early; Eric J. Bluhm; Shannee Babai; Neil L. Kelleher
Nucleic Acids Research 2007; doi: 10.1093/nar/gkm371
A tool for determining all protein forms in a ProSightPC PTM Warehouse™ that have a theoretical mass within a user-specified tolerance of a given value
ProSight PTM 2.0 allows identification and characterization of both intact proteins and peptides. Our PTM Warehouses are annotated with all known post-translational modifications (PTMs), alternative splicing events and single nucleotide polymorphisms (SNPs) using the technique of Shotgun Annotation developed in the Kelleher Research Group. ProSightPTM is the only proteomics software that allows the user to search their tandem MS data against PTM Warehouses containing the known biological complexity present in UniProt.
Don't guess where the PTMs are, use ProSight.
ProSightPC 2.0 allows analysis of Thermo Fisher .RAW LC-MS/MS data. ProSightPC provides:
Contact your local Thermo Fisher sales representative for more information about ProSightPC 2.0, currently launched!!
If your research involves the analysis of neuropeptides, please visit neuroProSight for the unique ability to search for neuropeptides against an annotated prohormone warehouse. neuroProSight is supported by the UIUC Center for Neuroproteomics on Cell-Cell Signaling funded by the National Institute on Drug Abuse Grant P30 DA 018310.
The list of currently supported PTM Warehouses for ProSightPTM is available here.
Dr. John Garavelli is assisting us by incorporating the RESID database of post-translational modifications. We gratefully acknowledge these sources of generous support:
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